Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: where to go?
نویسندگان
چکیده
منابع مشابه
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis: where to go?
Enormous progress has been made during the last 25 years in our understanding of the aetiopathogenesis of the anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV). This has led to improvements in early diagnosis, treatment and secondary prevention of these diseases. Nevertheless, there are still unmet needs in the AAV. With respect to diagnosis and follow-up, sensitive ...
متن کاملClinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type.
OBJECTIVE To evaluate whether the classification of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) according to ANCA type (anti-proteinase 3 (PR3) or anti-myeloperoxidase (MPO) antibodies) predicts treatment response. METHODS Treatment responses were assessed among patients enrolled in the Rituximab in ANCA-associated Vasculitis trial according to both A...
متن کاملC5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis
INTRODUCTION The complement system is crucial for the development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). In particular, C5a plays a central role. In this study, plasma and urinary levels of C5a as well as renal C5a receptors (CD88 and C5L2) expression were investigated in patients with AAV. METHODS Twenty-four patients with AAV in the active phase, 19 patie...
متن کاملPathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.
What drives human beings to classify? It seems as if it is within our nature to do so. Clinical classification systems for the systemic vasculitides were composed a long time ago, and they are constantly being revised and altered. The histopathological features of many diseases are so diverse that classification is called for. The histopathological classification for anti-neutrophil cytoplasmic...
متن کاملGenetic aspects of anti-neutrophil cytoplasmic antibody-associated vasculitis.
The genetics of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a complex area of investigation because of the low frequency of AAVs, the rarity of familial cases and the complexity of disease phenotypes. However, recent studies have been able to gather significant numbers of patients, and multicentre collaborative efforts have allowed the performance of two genome-wi...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2011
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2011.04355.x